FDA approves Zurampic
The U.S. Food and Drug Administration (FDA) has approved Zurampic (lesinurad), a URAT1 inhibitor for use in combination with a xanthine oxidase inhibitor (XOI) for the treatment of hyperuricemia associated with gout.
Important information about Zurampic
Some patients taking Zurampic may have kidney problems such as a sudden decrease in kidney function (acute kidney failure). This is more common when you take Zurampic without a xanthine oxidase inhibitor. You should always take Zurampic with a xanthine oxidase inhibitor.
What is Zurampic?
Zurampic is a prescription medicine used together with a xanthine oxidase inhibitor to lower uric acid levels in the blood in adult patients with gout.
Zurampic should not be taken without a xanthine oxidase inhibitor such as allopurinol or febuxostat.
Zurampic helps the kidneys remove uric acid from the body and is added to a xanthine oxidase inhibitor, which decreases the amount of uric acid your body makes.
It is not known if this medicine is safe and effective in children under 18 years of age.
Who should not take Zurampic?
Do not take Zurampic if you have:
severe kidney problems, received a kidney transplant or you are on dialysis
a fast breakdown of cancer cells that can lead to high uric acid (Tumor lysis syndrome)
a rare inherited condition that causes too much uric acid in the blood (Lesch Nyhan syndrome)
Before taking Zurampic
Before taking Zurampic, tell your healthcare provider about all of your medical conditions, including if you:
are pregnant or plan to become pregnant. It is not known if Zurampic will harm your unborn baby.
are breastfeeding or plan to breastfeed. It is not known if Zurampic passes into your breast milk. You and your healthcare provider should decide if you should take Zurampic while breastfeeding.
Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.
Zurampic may affect the way other medicines work, and vice versa. Especially tell your healthcare provider if you take:
medicine for heart problems or high blood pressure
medicine for high blood cholesterol
antifungals and antibiotics
valproic acid
aspirin
other medicines for gout
hormonal contraceptives. Women who use birth control medicines containing hormones to prevent pregnancy (birth control pills, skin patches, implants, and certain IUDs) should use a back-up method of birth control during treatment.
Source: www.drugs.com
