Experimental injection may protect against peanut allergy
People with peanut allergy must be constantly vigilant to avoid a life-threatening allergic reaction. But researchers report that a new drug injection might offer at least temporary protection against the most severe reactions. Just one shot of an experimental antibody treatment allowed people with severe peanut allergy to eat about one peanuts worth of peanut protein two weeks later, the study found.
The drug is like a protective blanket shielding people from accidental peanut exposure, said study senior author Dr. Kari Nadeau, director of the Sean N. Parker Center for Allergy and Asthma Research at Stanford University in California. Peanut allergy affects an estimated 2.5% of American children, and that number has risen sharply over the past decade, according to the American College of Allergy, Asthma and Immunology (ACAAI).
Children and adults with a peanut allergy are at risk of having a sudden and severe allergic reaction (anaphylaxis) that can be life-threatening if they consume even small amounts of peanuts.
The problem is that peanuts are in many foods, such as candy, cereal, baked goods, sauces, marinades and even in ice cream, according to the ACAAI.
That means people with peanut allergies have to be extra-careful about what they eat at home, and often have to limit the places theyll eat at away from home. For example, many Asian foods are made with peanuts or peanut sauces, and possibly fried in peanut oil.
Besides avoiding foods with peanuts, the only current treatment for peanut allergy is oral immunotherapy. This treatment requires people to eat tiny bits of the food theyre allergic to at their doctors office. The amount of the offending food is increased over time. Treatment can take six months to a year, and theyre at risk of an allergic reaction during the process, the study authors explained.
The drug tested in the trial works in a different way. Called etokimab, the drug interferes with the action of a substance called interleukin-33 (IL-33). IL-33 triggers a cascading response that causes an allergic reaction when exposed to an allergen, such as a peanut.
The researchers tested the new medication on 15 adults with a severe peanut allergy. They were given a single injection of etokimab. Another five people with severe peanut allergies received a placebo injection.
Fifteen days later, they all consumed a small amount of peanut protein under medical supervision. They were given the food challenge again 45 days after the drug injection. At 15 days, 73% of those treated were able to eat the equivalent of protein from one peanut. By day 45, just 57% who received the drug were able to pass the food challenges. People given the placebo couldnt tolerate the peanut protein at either time.
We were surprised to see an effect that was so dramatic, Nadeau said.
Because this was a small, phase 2 clinical trial, Nadeau said larger studies that include younger patients and patients from more than one medical center are still needed.
A lot of questions remain, too. For example, is there an additive effect after more than one shot? Will the drug last a different amount of time for different people? And does it work for other types of food allergies? Nadeau said in theory, it should work for other food allergies as well.
HealthDay
